Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical needs and pharmacology regarding curcumin
Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin ‘s the big element of the brand new yellow color from turmeric, a keen Indian spice that is obtained from the brand new rhizome of warm bush Curcuma longa, which belongs to the Zingiberaceae friends. Within chapter, i talk about the pharmacological points out of curcumin and you can speak about new molecular angles for those products. We then remark the demonstrated and possible medical uses out of curcumin. Curcumin is famous over the years since a restorative agent, however, their system off action is actually detailed. The new pharmacological ramifications of curcumin seem to be the result of an effective synergism out-of communities regarding weakened biochemical dejta vackra Arabisk kvinnor connections with numerous physical needs for the interconnected signaling pathways. These targets tend to be nutrients such cyclooxygenase, lipoxygenase and you can necessary protein kinases, and transcription items such NF-?B, STAT and Nrf2. Modulation of these molecules influences downstream affectors that produce the fresh antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you will antimicrobial products of curcumin. These consequences was basically looked at within the scientific products out-of curcumin to own soreness and you will inflammatory problems, cancers, Alzheimer problem, cardiovascular ailment, and diabetic issues. The products used variable dosages regarding curcuminwith various other frequencies and years, into standard achievement one to high dosage out of curcumin in the number of grams have to receive healing effects. Read more
Curcumin: Synthesis, Growing Part in the Aches Administration and you may Health Ramifications
Publication Section Samples of plant-derived pharmaceuticals that have get to be the attract out of proceeded and you can great search and you can advancement notice has actually, up until now, started a bit scarce. Immediately following years, the very last 2 decades were characterized by a good 100-flex increase in the amount of scientific blogs authored annually you to is out-of importance into accessibility curcumin into the biomedicine. Find out more
Framework, synthesis and you may biological products of curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has some potential pharmacological effects and could have therapeutic programs in lot of problem claims, while the discussed in detail in the earlier chapter. However, the possibility logical effectiveness off curcumin is bound of the its physicochemical qualities away from terrible liquids solubility and you can instability, and this end in reasonable bioavailability. Prodrugs regarding curcumin give ways to improvement of your biopharmaceutical and pharmacokinetic features, and may also ensure it is exploitation of one’s pharmacological results of curcumin. Contained in this section, i first comment the fresh new physicochemical and you can pharmacokinetics out of curcumin. We next establish the appearance of curcumin prodrugs which have enhanced liquid solubility and you can increased chemicals stability and this can be translated back to free curcumin upon bioactivation in vivo. I high light current triumph of this type, having a focus on the framework, synthesis and you may evaluation from prodrugs according to promoieties and additionally proteins, efas, nucleic acids, dicarboxylic acids, and you may polymeric materials eg hyaluronic acid and you will polyethylene glycol. That it chapter provides the reason for optimization of your own physicochemical and you can biopharmaceutical features therefore the physiological circumstances away from curcumin prodrugs, on the objective using ones curcumin types within the scientific applications. Read more